• SAR131675: Selective VEGFR-3 Inhibitor

  2026-09-02

  SAR131675 is a selective ATP-competitive VEGFR-3 inhibitor with nanomolar activity in recombinant kinase, cell-based autophosphorylation, lymphatic endothelial survival, and migration assays. The compound supports preclinical lymphangiogenesis, angiogenesis, and tumor growth inhibition research, but its development was discontinued after adverse metabolic effects in preclinical studies.

• Adamtsl3, MMP9, and Cortical Plasticity

  2026-09-02

  The reference study identifies Adamtsl3 as a cell-autonomous regulator of perineuronal net integrity in parvalbumin-positive interneurons and links its loss to elevated MMP9 activity, reduced Otx2 uptake, oxidative stress, and renewed adult cortical plasticity. Its genetic, morphological, biochemical, and pharmacological design provides a framework for testing how extracellular-matrix remodeling contributes to schizophrenia-related circuit dysfunction.

• Nelfinavir Mesylate in HIV and Ferroptosis Research

  2026-09-01

  Nelfinavir Mesylate combines a well-defined HIV-1 protease inhibition workflow with an emerging application as a chemical probe of ferroptosis-linked proteostasis. This guide explains how to build concentration-response assays, connect antiviral and DDI2-NFE2L1 readouts, and troubleshoot solubility, cytotoxicity, and interpretation challenges.

• DMXAA (Vadimezan) Tumor Vascular Assay Guide

  2026-09-01

  Build more informative tumor-vascular experiments with DMXAA (Vadimezan), combining endothelial apoptosis, VEGFR2 signaling, and tumor-cell response measurements. This workflow also shows how the endothelial STING-JAK1 findings can refine assay interpretation without incorrectly assigning a direct STING mechanism to DMXAA.

• Scalable EPSC-iMSC Extracellular Vesicles for Fibrosis

  2026-08-31

  Gong et al. developed a bioreactor-based platform that converts extended pluripotent stem cells into expandable induced mesenchymal stromal cells and produces extracellular vesicles at a clinically relevant scale. The resulting vesicles showed characteristics and pulmonary antifibrotic activity comparable to primary MSC-derived vesicles, addressing major reproducibility and manufacturing barriers.

• Sex Differences in Angiotensin II Hypertension

  2026-08-31

  Xue, Pamidimukkala, and Hay used telemetry in conscious mice to show that chronic angiotensin II produces a substantially larger pressor response in males than in females. Their design links this divergence to gonadal status, baroreflex resetting, and sympathetic maintenance of blood pressure, providing a useful framework for sex-stratified cardiovascular experiments.

• Laminin (925-933) for Adhesion & Chemotaxis

  2026-08-30

  Laminin (925-933) is a defined Laminin B1 chain peptide for controlling cell attachment, receptor-mediated migration, and chemotaxis without the compositional variability of full-length extracellular matrix. This workflow-focused guide explains how to deploy it in cancer, neurobiology, and basement membrane protein research while using the tau study as a model for choosing context-appropriate ex vivo assays.

• Fast-Dissociating Antibodies by Single-Molecule Screening

  2026-08-29

  Miyoshi et al. developed a semi-automated single-molecule TIRF assay that identifies specific, fast-dissociating monoclonal antibodies directly from hybridoma cultures. The resulting Fab probes support multiplexed super-resolution imaging and revealed rapid espin turnover within the stable F-actin cores of inner-ear hair-cell stereocilia.

• Prestained Protein Marker: Triple Color Workflow

  2026-08-28

  This defined 10–250 kDa prestained ladder provides visible size references for SDS-PAGE, transfer checks, and Western blot protein size verification without added loading buffer or heat incubation. It is suited to routine electrophoresis, Phosbind SDS-PAGE, and fluorescent membrane imaging workflows, but it should not be used as a quantitative protein assay standard or as proof of uniform transfer for every sample protein.

• Shufeng Xingbi Therapy in Allergic Rhinitis Rats

  2026-08-28

  A 2025 bioRxiv preprint examines how Shufeng Xingbi Therapy affects allergic rhinitis in rats by integrating nasal inflammation, Th1/Th2-associated signaling, serum mediators, short-chain fatty acids, and intestinal microbiota. Its main contribution is a gut–immune–nasal framework for interpreting a traditional medicine intervention, while the preprint status and limited causal controls require careful translational interpretation.

• Gly-Gly-Phe-Gly (GGFG) Peptide Guide

  2026-08-27

  Gly-Gly-Phe-Gly, also called the GGFG peptide, is a short peptide linker for research in drug conjugation, peptide engineering, and biomaterial construction. The C8670 product is a 98% pure solid with a catalog-reported molecular weight of 336.34 g/mol, but it is not itself evidence of therapeutic efficacy.

• PFHxS Hepatotoxicity Through PPAR Signaling in Zebrafish

  2026-08-27

  A 2024 Environmental Science & Technology study shows that environmentally relevant perfluorohexanesulfonic acid exposure damages the developing zebrafish liver through PPAR-associated signaling. Its combination of transcriptomic discovery, tissue-level pathology, biochemical testing, targeted expression analysis, pharmacological antagonism, and PPAR knockdown provides a stronger mechanistic framework than single-endpoint toxicity testing.

• Perospirone in Receptor and Kv1.5 Assays

  2026-08-26

  Perospirone supports paired studies of receptor pharmacology in schizophrenia research and off-target vascular ion-channel activity. This workflow links serotonergic and dopaminergic signaling pathways with Kv1.5-focused electrophysiology while emphasizing solvent control, concentration selection, and interpretation limits.

• Sabutoclax: From Target Engagement to Translation

  2026-08-26

  Sabutoclax offers a multi-target approach to apoptosis resistance by inhibiting Bcl-2, Bcl-xL, Mcl-1, and Bfl-1. This thought-leadership guide shows how translational researchers can connect target engagement, time-resolved cell-death measurements, model selection, and preclinical interpretation without confusing growth arrest with actual killing.

• Sodium Oxamate Workflows for LDH-A Studies

  2026-08-25

  Sodium Oxamate provides a water-compatible way to suppress LDH-A activity, quantify lactate-dependent phenotypes, and dissect metabolic resistance mechanisms. This practical guide connects dose-response design with lactylation, DNA-repair, bioenergetic, and radiotherapy assays.

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