• Materials and methods Standard curve for http

  2022-02-25

  

  Materials and methods Standard curve for methylglyoxal. Different concentrations (10, 25, 50, and 100μM) of pure MG (Sigma) were derivatized with 1,2-diaminobenzene and the absorbance of the resulting derivative was read by Cary 50 Bio UV-Visible spectrophotometer (Varian). One milliliter of total

• In this study we examined whether zebrafish ionocytes might

  2022-02-25

  

  In this study, we examined whether zebrafish ionocytes might also share other types of similarity in transport function with kidney cells. In addition to ion transport, mammalian kidney ICI 118,551 hydrochloride also play key roles in xenobiotic elimination, through the action of ATP-Binding Casset

• A main finding of this study was that the impact

  2022-02-25

  

  A main finding of this study was that the impact of exogenous insulin on hippocampal memory and glucose utilization was GluT4-dependent. Although insulin was administered directly to the hippocampus, it is important to point out that such administration does indeed have physiological relevance; that

• br Experimental section br Introduction Fasting hyperglycaem

  2022-02-25

  

  Experimental section Introduction Fasting hyperglycaemia in all forms of diabetes mellitus occurs primarily as a result of upsurge in hepatic glucose synthesis (HGS) [1], [2]. Two specific enzymes, glucokinase (GK) and glucose-6 phosphatase (Glu-6-Pase) play crucial role in hepatic glucose pro

• In the second part of this study

  2022-02-25

  

  In the second part of this study, we investigated the influence of GH on the Schizandrin A of the ghrelin receptor, GHSR-1a, at the mRNA and peptide levels in cultured whole follicles. Regulation of the expression of GHSR-1a has a key role in the actions of ghrelin in target tissues. Using RT-PCR a

• 98 2 ATN Ac PHSCN NH is a

  2022-02-24

  

  ATN-161 (Ac-PHSCN-NH2) is a small peptide antagonist of integrin α5β1, a recently developed anticancer drug that interacts with the N-terminus of the β1 region of integrin α5β1 to lock integrin α5β1 in its non-activated conformation (Wang et al., 2016). The drug has been tested in Phase 2 clinical t

• br The HDC knockout mouse as

  2022-02-24

  

  The HDC knockout mouse as a pathophysiological model of TS The implication of a hypomorphic allele of the Hdc gene as a rare cause of TS (Ercan-Sencicek et al., 2010) created a rare opportunity for the generation of a pathophysiologically grounded model of the disorder. Modeling pathophysiology o

• The repurposing of well characterized

  2022-02-24

  

  The repurposing of well-characterized and well-tolerated drugs in order to treat illnesses for which they were not originally intended has emerged as an attractive alternative to a long and costly process of drug development. Repositioning antihistaminergic ligands seems a promising idea given that

• br Results br Discussion Our current study demonstrates

  2022-02-24

  

  Results Discussion Our current study demonstrates that the sustained activation of Yap overrides the p27-mediated checkpoint, at least in part, through the degradation of FoxO family proteins, allowing polyploid cells to proliferate inappropriately with mitotic defects and resulting in centros

• br Conclusion Infections caused by the P aeruginosa could

  2022-02-24

  

  Conclusion Infections caused by the P. aeruginosa could not be cured by current antibiotics, making multiple drug resistance of P. aeruginosa an increasing threat for human lives. Looking for a new therapeutic mechanism for infections caused by the P. aeruginosa has become a central issue. There

• Numerous strategies of cardiomyocyte protection are effectiv

  2022-02-24

  

  Numerous strategies of cardiomyocyte protection are effective in preclinical, animal models and in small clinical trials. However, most have disappointed in large clinical trials [4,5]. Failures of cyclosporine and post-conditioning to mitigate reperfusion injury are recent examples [[6], [7], [8]].

• Finally our work showed that HAART resulted

  2022-02-24

  

  Finally, our work showed that HAART resulted in significant inter-individual variability among DEGs, which reflected the BRD-K4477 in HIV-affected human gene expressions (Fig. 1, Fig. 2, Fig. 3, Fig. 4). These observations also highlighted the importance of determining common as well as personal sp

• There is sufficient evidence to indicate that

  2022-02-23

  

  There is sufficient evidence to indicate that kisspeptin plays a role in regulating sheep reproduction. However, the molecular mechanism by which kisspeptin regulates GnRH 5,7-dihydroxychromone mg and reproduction has remained unclear. Therefore, in this study on GnRH in sheep, the promoter region

• Because sleep and metabolism are intimately linked

  2022-02-23

  

  Because sleep and metabolism are intimately linked, the authors next move to study whether Eaat2 also controls metabolic rate. First, we must ask how sleep and metabolism are connected at a functional level. The Caspase Inhibitor Set I allocation hypothesis of sleep posits that organisms temporally

• else FFAR is highly expressed not only in cells but also

  2022-02-23

  

  FFAR1 is highly expressed not only in β cells but also in α else (Segerstolpe et al., 2016), which gives the interesting perspective that 20-HETE may function both as an autocrine and as a paracrine regulator of islet cell function (Figure 1A), i.e., acting in symphony with the many other intra-isl

15815 records 485/1055 page Previous Next First page 上5页 481482483484485 下5页 Last page