• In contrast to PEGylated proteins which

  2020-05-06

  

  In contrast to PEGylated proteins which tend to have reduced Moxifloxacin in the body relative to their native counterparts, proteins conjugated to albumin tend to accumulate in certain locales in vivo. This means that albumin-based drug carrier systems have particular applications in the field of c

• Estrogen receptors ERs belong to

  2020-05-06

  

  Estrogen receptors (ERs) belong to the third class of nuclear receptors (NR3) [23]. Two different forms of ER have been described, ERα and ERβ. They are coded by two distinct genes (ESR1 and ESR2, respectively) containing 8 transcribed exons that give rise to six conserved protein domains: domains A

• Quantum dots QDs which exhibit excellent fluorescence

  2020-05-06

  

  Quantum dots (QDs), which exhibit excellent fluorescence quantum yields (QYs), high extinction coefficients and size-tunable narrow emission have highly attracted great interest in various applications such as in solar cells, sensors, and bioimaging [16], [17], [18], [19], [20]. However, QDs suffere

• br Introduction The protein Epidermal Growth Factor Receptor

  2020-05-06

  

  Introduction The protein Epidermal Growth Factor Receptor Tyrosine Kinase (EGFR-TK) play important role in non small-cell lung carcinoma (NSCLC) and vital therapeutic progress withinin the treatment of this ailment has revamped the past ten years through the exploitation of this insight (Mok et a

• br Cytokines potent mediators of ILC function The

  2020-05-06

  

  Cytokines – potent mediators of ILC function The different ILC players are portrayed in three categories, ILC1, ILC2 and ILC3, based on the cytokines they produce and transcription factors (TFs) that guide their differentiation [8] (Figure 1). Cytokines are the most extensively studied stimuli fo

• The protein levels of the three

  2020-05-05

  

  The protein levels of the three enzymes in the organs in the three earthworm species ranked body wall > intestine > seminal receptacle ≈ seminal vesicle (Fig. 3B).The presence of significant detoxification capability in the body wall would be logically expected in a soil dwelling organism, to facili

• Based on the ability of CRF to modulate nociception

  2020-05-05

  

  Based on the ability of CRF to modulate nociception, we hypothesized that stress leads to hyperalgesia by the activation of CRF1 and/or CRF2 receptors in the spinal cord. We tested this hypothesis using an acute forced swim as a widely used and easily reproducible stressor and grip force as a measur

• The use of AACSB accreditation as an

  2020-05-05

  

  The use of AACSB accreditation as an indicator of expected performance on the CPA exam has been examined by prior studies (e.g. Barilla et al., 2008, Boone et al., 2006, Grant et al., 2002, Howell and Heshizer, 2006, Lindsay and Campbell, 2003, Marts et al., 1998). While these studies are based on d

• Enlarging the ligand binding pocket by reduction of the size

  2020-05-05

  

  Enlarging the ligand-binding pocket by reduction of the size of the residue F435 switched DES to an agonist indicating that F435 is involved in mediating the antagonistic effect of DES (Fig. 7E) [13]. The conformation of the smaller side chain of L435 was either not altered by DES or was too small t

• Culture conditions particularly temperature which affect

  2020-05-05

  

  Culture conditions (particularly temperature), which affect the pathogenicity of Y. enterocolitica (Bottone, 1997), may also impact its inhibitory properties against cysteine proteases. However, culturing the bacterial strains at 37 instead of 28 °C did not alter remarkably the inhibitory potential

• Several of the keloid like

  2020-05-05

  

  Several of the keloid-like lesions seen in these individuals were pigmented. It is of potential relevance that genetic variants in DDR1 [MIM: 600408] have been associated with vitiligo, and DDR1 activation is involved when crth2 antagonist are attached to collagen-IV fibers. Because DDR1 and DDR2 ar

• In the current study cocaine did not significantly increase

  2020-05-05

  

  In the current study, cocaine did not significantly increase negative subjective effects and nepicastat did not increase these responses. This outcome is somewhat surprising given that the most commonly reported effect to date has been to increase the aversive properties of cocaine such as anxiety,

• fructose 1 6 bisphosphatase High throughput screening HTS of

  2020-05-05

  

  High throughput screening (HTS) of the AstraZeneca fructose 1 6 bisphosphatase collection was conducted and identified oxadiazole amide () originating from a kinase directed screening library (although inactive against a panel of kinases). This compound had moderate potency as a DGAT-1 inhibitor (IC

• br Future direction and conclusion br Conflict of interest

  2020-05-05

  

  Future direction and conclusion Conflict of interest References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Introduction Colony stimulating factor-1 (CSF-1; also referred to as the macrophage-colony stimulating

• Cryoprotectant equilibration and the response to ice concent

  2020-05-05

  

  Cryoprotectant equilibration and the response to ice concentrated media are the two facets of cellular cryobiological protocols most commonly covered by mathematical modeling. In these models, n-acetyl-l-cysteine are typically assumed to have uniform, spatially independent extracellular concentrati

14989 records 795/1000 page Previous Next First page 上5页 791792793794795 下5页 Last page