• According to the labeling of dabigatran in Japan patients to

  2019-06-11

  

  According to the labeling of dabigatran in Japan, patients to be considered for the prescription of the lower dose of 220mg/day are as follows: (1) aged ≥70 years, (2) with moderate renal impairment (ClCr 30–50mL/min), (3) concomitant use of a p-glycoprotein inhibitor, and (4) history of hemorrhage

• Mechanistic target of rapamycin mTOR a highly conserved seri

  2019-06-11

  

  Mechanistic target of rapamycin (mTOR), a highly conserved serine-threonine protein kinase, is a key regulator of cell growth and metabolism. As discussed above, mTORC1 is a negative regulator of the preinitiation complex that modulates the initiation of autophagosome biogenesis. Pharmacological and

• Worldwide there are an estimated

  2019-06-11

  

  Worldwide, there are an estimated 1 112 727 specialist surgeons (IQR 1 059 158–1 177 912), 550 134 anaesthesiologists (529 008–572 916) and 483 357 obstetricians (456 093–517 638; ). Low-income and lower-middle-income countries, representing 48% of the global population, have 20% of this workforce,

• Seg n Patricia Fagen en su

  2019-06-11

  

  Según Patricia Fagen, en su estudio clásico sobre el exilio español, “un numero sorprendente de jóvenes participaron en el Movimiento 1959 y muchos más hubieran participado si hubiesen creído que había algo significativo con lo que hubieran podido contribuir”. El espíritu de ruptura con las disputas

• Con Lemebel y Perlongher y

  2019-06-11

  

  Con Lemebel y Perlongher, y la resonancia que en ellos tienen Gilíes Deleuze y Félix Guattari, puede percibirse un gesto de queeridad sudamericano, un “infinito devenir minoritario, nómade, siempre en movimiento, en el que podemos leer la emergencia de una mirada que se acerca rho kinase inhibitor l

• Perhaps counter intuitively the most strategic tobacco contr

  2019-06-11

  

  Perhaps counter-intuitively, the most strategic tobacco control policies to reduce adolescent smoking and secondhand smoke exposure in LMICs may not be those targeting adolescents. Targeted campaigns can be expensive, and are unlikely to be as effective as the more affordable tobacco control policie

• br Acknowledgments This work was supported by grants from th

  2019-06-11

  

  Acknowledgments This work was supported by grants from the National Science Council (project number: MOST-103-2320-B-040-004 and NSC 102-2313-B-002 -039 -MY3). The authors would like to thank Dr. Bernard A. Schwetz for carefully reading the manuscript and helpful discussions which improved the ar

• br Case report A year old man

  2019-06-11

  

  Case report A 54-year-old man with a surgically repaired DORV was admitted to our hospital due to palpitations and worsened right ventricular heart failure. He had been diagnosed with DORV and had undergone the Blalock Taussig operation at 7 years of age. He underwent the Rastelli operation at 35

• br Introduction Epidemiological studies have shown that vira

  2019-06-11

  

  Introduction Epidemiological studies have shown that viral infections such as hepatitis C virus (HCV) and hepatitis B virus (HBV) are important factors contributing to hepatocellular carcinoma (HCC) development. Chronic HCV leads to cirrhosis in approximately 20% of patients over a 10–20 year per

• Visto el franquismo como el gran eje de la discordia

  2019-06-10

  

  Visto el franquismo como el gran eje de la discordia, el punto de in flexión se produjo en 1949 con motivo de la presentación en la onu de una propuesta conjunta de cuatro países de América Latina: Brasil, Bolivia, Colombia y Perú. La propuesta de resolución del cuatripartito latinoamericano (proyec

• br INTRODUCCI N Con la

  2019-06-10

  

  INTRODUCCIÓN Con la incorporación de los derechos colectivos de los pueblos indígenas en la normatividad internacional de los derechos humanos, se inicia una nueva etapa en la conflictiva relación entre las bases fundacionales del poder político moderno y la diversidad cultural, en tanto aquellas

• Yang et al reported PSA triggered TRUSP biopsy

  2019-06-10

  

  Yang et al. reported PSA triggered TRUSP biopsy in Korea. This study included 75 patients younger than 40 years of age, with PSA > 4.0 ng/mL; the PCa detection rate was 1.3% in the Korean study. In comparison, there were substantially more abnormal DRE findings and significant LUTS findings in our s

• HRU resulting from SREs is of increasing relevance

  2019-06-10

  

  HRU resulting from SREs is of increasing relevance in times of financial and economic restraint because it can help to determine the financial burden to hospital managers and payers. A separate analysis of the costs associated with SREs in this study found that the most costly SRE, spinal cord compr

• molarity and dilution Many studies over the past years have

  2019-06-10

  

  Many studies over the past 20 years have shown the potential of urinary markers in the detection of the presence of bone metastases [3–11], the use of urinary markers for its prognostic value in bone disease [2,4,12–20], as well as directing therapy for bone metastases patients [2,6,12–18,21–25]. Th

• br Meses m s tarde en Un

  2019-06-10

  

  Meses más tarde, en “Un monosindicato que se adhiere pi3 kinase las huelgas” (, 14/enero/1935), Max Carón incluye un pliego petitorio donde delata y, a la vez, desvirtúa la profesión de su alter ego, la de traductor de cables del inglés y del francés: “Obligación de Gilberto Owen (el señor de la a

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