• In this study we investigated the role

  2019-07-02

  

  In this study we investigated the role 17-phenyl tinor (pt)-PGE2 on endothelial barrier function and the underlying molecular mechanism in HMVEC-Ls as well as in a murine model of LPS-induced acute pulmonary inflammation. We found that 17-pt-PGE2 concentration-dependently enhanced endothelial barrie

• Previous research has suggested that

  2019-07-01

  

  Previous research has suggested that the acetylcholine-gated chloride channels (ACCs) in Caenorhabditis elegans (Putrenko et al., 2005) exhibit the characteristics of promising drug targets. The genes that encode the various subunits of this family are present across the nematode phylum and appear t

• Rat pheochromocytoma PC cells have been widely

  2019-07-01

  

  Rat pheochromocytoma PC12 cells have been widely used as a cell system to study intracellular signaling leading to neurite outgrowth. The advantages of using PC12 cells in the CHK studies are the fact that they naturally express the rat form of CHK and the observation that down-regulation of CHK fun

• In conclusion through a series of experiments we showed

  2019-07-01

  

  In conclusion, through a series of experiments we showed that our antigen LALF32-51-E7 combined with alum adjuvant promotes a Th1 immune response and consequently an anti-tumor response in the TC-1 tumor model. Based on our results, we suggest not to underestimate the capacity of Al(OH)3 as adjuvant

• br Conclusion Conduction disorders were localized and inhomo

  2019-07-01

  

  Conclusion Conduction disorders were localized and inhomogeneous in patients with ischemic heart disease, in whom CRT efficacy was slightly low; therefore, detailed optimization using echocardiography, radioisotopes, Swan–Ganz catheterization, and other methods should be carefully performed as ne

• Cost effectiveness is another major concern

  2019-07-01

  

  Cost effectiveness is another major concern for the governments in countries with public health system. Van-den Hout WB et al. at Netherlands [7] did a cost utility analysis showing the cost of radiation treatment including re-treatment for bone metastases using SF versus MF were €2438 versus €3311

• br Management of warfarin during pacemaker implantable cardi

  2019-07-01

  

  Management of warfarin during pacemaker/implantable cardioverter defibrillator insertion Until recently, warfarin use was halted before PM/ICD insertion and the patient was bridged with intravenous (IV) unfractionated heparin or subcutaneous low-molecular-weight heparin (LMWH) if the thromboembol

• ionomycin weight It is noteworthy that in a recent

  2019-07-01

  

  It is noteworthy that in a recent study, Le Scouarnec et al. [199]. estimated the burden of rare coding variation in arrhythmia susceptibility genes among 167 BrS index patients and compared that with 167 individuals ≥65 years old with no history of cardiac arrhythmia. The authors concluded that, ex

• In their analysis the investigators did not include common c

  2019-07-01

  

  In their analysis, the investigators did not include common causes of CKD in sub-Saharan Africa other than HIV, diabetes, and hypertension—notable omissions were chronic glomerulonephritis and use of herbal or traditional treatments. Also, communicable diseases might contribute substantially to CKD

• In several Western reports from large

  2019-06-29

  

  In several Western reports from large-scale comparative studies and epidemiological surveys, there was no significant difference in the incidence of thromboembolism between paroxysmal and persistent AF patients [46,47]. Data from our institution suggested that the incidence of cardiogenic thromboemb

• Cryotherapy related soft tissue injury usually occurs within

  2019-06-29

  

  Cryotherapy related soft tissue injury usually occurs within a few weeks postoperatively. Skin necrosis is a significant complication if freezing of the superficial surface occurs. Constant irrigation of the adjacent tissues with warm saline reduces the chance of skin necrosis. Our rate of infection

• br Conclusion br Funding br Conflict of interest br

  2019-06-29

  

  Conclusion Funding Conflict of interest Introduction Over the last decade, the unabated increase in the number of transseptal catheterizations has been related to an increase in atrial fibrillation (AF) ablation procedures. Transseptal puncture (TP) is usually safe in experienced hands [

• The type of ventricular arrhythmia monomorphic VT or polymor

  2019-06-29

  

  The type of ventricular arrhythmia (monomorphic VT or polymorphic VT/VF) responsible for the electrical storm provides an important diagnostic clue to its pathophysiology (Fig. 1). In this review, we address the diagnosis and specific treatments according to the type of ventricular arrhythmia and th

• The clinical spectrum of intracranial hemorrhage is similar

  2019-06-29

  

  The clinical spectrum of intracranial hemorrhage is similar for patients treated with warfarin and dabigatran [10]. Absolute rates of intracranial hemorrhage across all sites and of both fatal and traumatic intracranial hemorrhages are lower with dabigatran than with warfarin [10]. Concomitant aspir

• Anidulafungin of br Outstanding questions br Conflict of int

  2019-06-29

  

  Outstanding questions Conflict of interest Acknowledgments This work was supported by the Dutch Cancer SocietyUL2015-7599 KWF (EZ). Platelets and cancer metastasis Blood platelets play a primary role in wound healing and hemostasis. Since the first observation made (on himself) by the s

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