• br Genetic rescue of GluR A dependent spatial working

  2022-07-04

  

  Genetic rescue of GluR-A-dependent spatial working memory Spatial working memory performance in GluR-A−/− mice can be restored by the forebrain-specific Dorsomorphin of GluR-A subunits labeled with green-fluorescent protein (GFP) on an otherwise GluR-A knockout background (Schmitt et al., 2005).

• During the tests in vitro SHP showed

  2022-07-04

  

  During the tests in vitro, SHP289-04 showed the beneficial effect on both two important aspects. In human liver carcinoma cell line HepG2, it was found to improve glucose consumption significantly. Otherwise, in pancreas cell line NIT1, it could only promote insulin secretion significantly at high g

• In a meta analysis of genome wide association studies a

  2022-07-04

  

  In a meta-analysis of genome-wide association studies, a variant (rs10423928) in the GIPR gene has been found to be associated with elevated postprandial glucose and insulin (Saxena et al., 2010) as well as lean body composition including decreased BMI, lean mass and waist circumference (Lyssenko et

• All of the abovementioned effects of PUFAs signal their

  2022-07-04

  

  All of the abovementioned effects of PUFAs signal their involvement in a cellular phenotype switching phenomenon, which is increasingly recognized as a potential target for future pharmacotherapies of atherosclerosis, especially for individuals who do not respond to the classical lipid-lowering stra

• The site of paracetamol action remains controversial Some pu

  2022-07-02

  

  The site of paracetamol action remains controversial. Some publications are in favor of a central action (Barrière et al., 2013, Dogrul et al., 2012, Mallet et al., 2010, Pickering et al., 2006), while others report a peripheral action (Dani et al., 2007, Ferreira et al., 1978). FAAH is a ubiquitous

• SKL2001 br Conflict of interests br Acknowledgements This wo

  2022-07-02

  

  Conflict of interests Acknowledgements This work was supported by the National Institutes of Health grants HD058577 and ES01678 to Kirill Kiselyov. We thank Sreeram Ravi for technical support. We also thank Mike Myers at the University of Pittsburgh Cancer Institute Flow Cytometry Facility.

• This study appears to provide an additional

  2022-07-02

  

  This study appears to provide an additional example, albeit an unanticipated one, of the importance of renal ETB receptor function in the normal control of blood pressure and salt and water homeostasis. ETB receptor-deficient rats, collecting duct-specific ETB receptor knockout mice, and rats chroni

• There are many histone H K demethylases including JMJD

  2022-07-02

  

  There are many histone H3K9 demethylases, including JMJD1 A, JMJD2 A, JMJD2B, and JMJD2C (Kooistra and Helin, 2012). Considering that EPO agenerase synthesis is regulated by hypoxia, we further analyzed several hypoxia-induced H3K9 demethylases, such as JMJD1 A, JMJD2B and JMJD2C (Beyer et al., 2018

• In this paper we demonstrate a diatomaceous earth based

  2022-07-02

  

  In this paper, we demonstrate a HG-9-91-01 mg based TLC-SERS sensing technique combined with machine learning analysis to quantitatively detect seafood allergen in real spoiled tuna samples. We fabricate a diatomaceous earth TLC plate as a separable SERS-active substrate to detect histamine in arti

• Numerous strategies of cardiomyocyte protection are effectiv

  2022-07-01

  

  Numerous strategies of cardiomyocyte protection are effective in preclinical, animal models and in small clinical trials. However, most have disappointed in large clinical trials [4,5]. Failures of cyclosporine and post-conditioning to mitigate reperfusion injury are recent examples [[6], [7], [8]].

• br The serine threonine kinase haspin

  2022-07-01

  

  The serine/threonine kinase haspin (ploid Germ Cell-pecific Nuclear rote Kinase, also known as erm Cell-pecific ene-2; Gsg2) functions in mitosis, where it phosphorylates histone H3 at Thr-3 (H3T3ph). During mitosis, this phosphorylation generates a binding site on H3 for Survivin and thereby posi

• br For some time it was known that

  2022-07-01

  

  For some time, it was known that membrane-bound guanylate cyclases (GCs) of photoreceptor Adapalene in the retina respond to changes in the [Ca]. Lolley and Racz observed that synthesis of cyclic GMP (cGMP) was stimulated at only low [Ca], concluding that Ca has an inhibitory effect on the regul

• br Acknowledgements br Funding This work

  2022-07-01

  

  Acknowledgements Funding: This work was supported by the Instituto Nacional de Biomedicina do Semiárido (INCT-IBISAB-CNPq), Edital MCT/CNPq N° 014/2010 - Universal and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Introduction Guanylin and uroguanylin are small, heat-

• Two different genes encode GSK

  2022-07-01

  

  Two different genes encode GSK-3 isoforms α and β that have very similar catalytic domains but significantly differ in their N- and C-termini. The α and β isoforms split from a common precursor approximately at the emergence of vertebrates, suggesting that at least one of the isoforms took on a new

• Retigabine dihydrochloride The mechanisms of action of MMF a

  2022-07-01

  

  The mechanisms of action of MMF and DMF are not well understood, but a growing body of evidence has demonstrated that DMF may act on both the neurodegenerative and inflammatory response of MS patients. The majority of the data related to the mechanism of action of DMF/MMF demonstrates the associatio

15688 records 400/1046 page Previous Next First page 上5页 396397398399400 下5页 Last page